When Mitt Romney's wife, Ann, was diagnosed with breast cancer in late 2008, one of the people who reached out to the couple was newly elected President Barack Obama.

It was one of the few personal interactions between Obama and Romney.

"He was kind enough to call our home when my wife was ill, and he said that he and Michelle had my wife in their prayers," Romney said in an interview after the call. "I said, 'Mr. President-elect, Ann and I have you in our prayers'. And we do."

Even as their political fates have become more entwined, Obama and Romney have had little opportunity to connect directly. In fact, when the Democratic president and the former Republican governor of Massachusetts stand alongside each other during Wednesday night's presidential debate in Denver, it will be their first face-to-face meeting in nearly five years.

"I don't really know him well," Obama said in an interview with The Associated Press. "I think Gov. Romney obviously has achieved extraordinary success with his businesses, and he's obviously very focused on achieving the presidency. He cares deeply about his family, and I think he cares deeply about his faith."

Romney has had similarly kind words about the president as a father and family man. But most of their descriptions of each other during the campaign are far less complimentary, and that probably will be the case in the debate.

Romney accuses the president of having "more European than American" views. Obama says Romney has written off half the country.

The two do have a few similarities. They're both graduates of Harvard Law School; Romney also has a business degree from the Ivy League university. Each is a multimillionaire, though Romney's estimated $250 million fortune far exceeds Obama's net worth of about $12 million.

When people get one of their first looks at the rivals standing side by side Wednesday, they'll see a Republican who is 14 years older and an inch taller than the 51-year-old president, who stands 6-feet-1.

Obama and Romney first met in 2004 at a gathering of Washington's political and media elite. Romney, then governor, and Obama, a senator-elect from Illinois, were picked by the Gridiron Club to deliver speeches at a black-tie dinner. The private event's festive atmosphere, however, meant their dueling speeches were more about cracking jokes than outlining their policy differences.

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Obama, Romney: Rivals With Little Personal History