The first week of the NFL season can be an odd one.

It's the first time since February that football games actually mean something, and it can sometimes take a little while to knock the rust off.

There's also not much we can go off of. Sure, we can look back on a slate of four preseason games, but that's an excercise in futility more often than not. Starters' playing time is severely limited in exhibition games, and teams are understandably guarded about how much of their playbook they're willing to put on tape.

So when it comes to handicapping the first week, things are never easy. With that in mind, here are this week's lines via Bovada.lv.

Indianapolis at Chicago (-9.5)

Colts rookie quarterback Andrew Luck gets his first taste of the NFL's regular season when he and the Colts take their show on the road to take on an improved Bears team.

Philadelphia (-9.5) at Cleveland

Is this the year the Eagles' dynasty finally takes flight? They'll get their first chance to flex their muscles against a likely hapless Browns club in Cleveland to open the season.

Buffalo at New York Jets (-3)

The Jets' circus gets under way under the big top at the Meadowlands, and it won't be easy with the improved Bills ready to prove that their offseason investments were money well spent.

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NFL Week 1 Lines Call for Texans to Roll, AFC West Nail-Biter on 'Monday Night Football'